Nitrofurazolidone is a nitrofuran derivative antibiotic that can be used to treat gastrointestinal disorders such as diarrhea, enteritis and gastric ulcer caused by bacteria and protozoa. Nitrofurazolidone is a broad-spectrum antimicrobial agent that inhibits common Gram-negative and positive bacteria.Nitrofurazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome. Furazolidone belongs to the family of Nitrofurans. These are compounds containing a furan ring which bears a nitro group.
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