Pharmacological action of Ulinastatin

Ulinastatin is a glycoprotein isolated from the fresh urine of healthy adult males. It consists of 143 amino acids with a relative molecular mass of about 67,000. Ulinastatin is a protease inhibitor, which inhibits various enzymes such as trypsin, α-chymotrypsin and other serine proteases, granulocyte elastase, hyaluronidase, thiolase and plasmin. It also has a stable lysosomal membrane, inhibits the release of lysosomal enzymes, inhibits the production of myocardial inhibitory factor (MDF), scavenges oxygen free radicals and inhibits the release of inflammatory mediators. Ulinastatin can also improve the immune function caused by surgical stimulation, abnormal protein metabolism and renal function, prevent damage to internal organs and cells caused by surgical stimulation, and improve the circulation state during shock.
Ulinastatin is a glycoprotein extracted from human urine and is a protease inhibitor. It has the effect of inhibiting various pancreatic enzyme activities such as trypsin and is commonly used for the treatment of pancreatitis. In addition, Ulinastatin has a stable lysosomal membrane, inhibits the release of lysosomal enzymes and inhibits the production of myocardial inhibitors, so it can be used in the rescue treatment of acute circulatory failure.