Synthesis method of Usinic acid

Usinic acid is a broad-spectrum antibiotic that has a strong inhibitory effect on most Gram-positive bacteria and also inhibits the growth of tuberculosis. If combined with a small amount of streptomycin, its inhibition of tuberculosis can be greatly enhanced.
Synthesis method of Usinic acid:
1. From the bark of coniferous forests such as sorghum (white pine) and pine trees, the stalks of the genus Pinus sylvestris and the genus Sylvestris are commonly known as tree moss. Oakmoss and tree moss extracts using benzene or ethanol as a solvent. The extract contains a large amount of a depsipeptide or a ketal compound. These compounds have a large molecular weight, are non-volatile, and do not have any aroma. These do not contribute to the aroma of the oakmoss and spruce products. After a series of treatments, one of the above-mentioned by-products, lichenic acid, can be obtained.
2. The lichens are dried and heated and extracted with acetone as a solvent. The extract is collected, concentrated to a small volume, placed in a cool place, and Usinic acid can be crystallized and recrystallized to obtain a pure Usinic acid.