What is Xylometazoline Hydrochloride

Xylometazoline Hydrochloride directly induces vasoconstriction induced by α1-adrenergic receptors in the nasal mucosa, thereby reducing blood flow, reducing inflammation and edema caused by inflammation, and clinically reducing acute and chronic rhinitis, sinusitis, and allergies. The symptoms of nasal congestion caused by diseases such as rhinitis and hypertrophic rhinitis have the characteristics of fast lifting speed, long-lasting effect and small side effects. The synthesis route is: 1,3-dimethyl-5-tert-butylbenzene as a starting material, and reacted with a chloromethylating reagent in the presence of a catalyst to obtain 2,6-dimethyl-4-oxo-butyl- 1-Chloromethylbenzene; cyanidation with sodium cyanide to give 2,6-dimethyl-4-t-butyl-1-phenylacetonitrile and then cyclization with ethylenediamine p-toluenesulfonate to give p-toluene Acid xylozoline (11); celazoline is obtained by dissociating celazoline with a base and then forming a salt with hydrogen chloride. The shortcomings of this process are: tert-butyl meta-xylene market price is higher; chloromethyl ether is more toxic, lower boiling point and higher market price; high-toxic solvent such as carbon disulfide, and low boiling point, poor reaction operability. Another synthetic route is: reacting 2,6-dimethyl-4-tert-butylaniline hydrochloride with sodium nitrite, copper sulfate and paraformaldehyde to form 2,6-dimethyl 4- After tert-butylbenzaldehyde is reduced to alcohol, it is then subjected to chloromethylation, hydrogenation, amino esterification, cyclization, or salt formation to form celazoline hydrochloride. The synthetic route has long steps and complicated post-treatment; after analysis and comparison, the diazotization reaction in the synthetic method generally has a low yield; while the use of thionyl chloride has a great pollution to the environment; it is difficult to enlarge the production, and the obtained product is obtained. More impurities, product purity. In short, the synthetic method has a long process route, complicated post-processing, low yield of finished products, high production cost, and difficulty in realizing industrialized large-scale production.